The Beginner's Guide to Microdosing Psilocybin

Microdosing has emerged as one of the most significant wellness trends of the decade. In this comprehensive guide, we explore what microdosing is, how it works, and how to begin your own practice safely and intentionally.

A microdose is typically defined as 1/10th to 1/20th of a recreational dose — enough to provide subtle cognitive and emotional benefits without producing perceptible psychoactive effects. The goal is not to trip, but to enhance your baseline functioning.

The Fadiman Protocol is the most widely studied approach: take one microdose every third day. Day 1 is your dose day, Day 2 is an afterglow day where residual benefits are felt, and Day 3 is a baseline day. This rhythm prevents tolerance buildup and allows integration.

The Stamets Stack, developed by mycologist Paul Stamets, combines psilocybin with lion's mane mushroom and niacin (vitamin B3). The protocol is 4 days on, 3 days off. Lion's mane promotes neurogenesis while niacin acts as a flushing agent to distribute compounds throughout the nervous system.

Intuitive dosing is a third option — dosing based on personal need rather than a fixed schedule. This approach works best for experienced practitioners who can read their body's signals.

Start low. Our Serenity capsules at 250mg are an ideal starting point for most people. Keep a journal — track your mood, energy, creativity, and social interactions. Pay attention to the subtle shifts in your awareness, creativity, and emotional resilience over the first 2-4 weeks.

Common benefits reported by microdosers include enhanced focus, improved mood, greater creativity, reduced anxiety, and a deeper sense of connection. These effects are typically subtle and cumulative rather than immediate and dramatic.